Browsing by Department "Department of Psychiatry and Mental Health"
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- ItemOpen AccessA biregional survey and review of first-line treatment failure and second-line paediatric antiretroviral access and use in Asia and southern Africa(2011)BackgroundTo better understand the need for paediatric second-line antiretroviral therapy (ART), an ART management survey and a cross-sectional analysis of second-line ART use were conducted in the TREAT Asia Paediatric HIV Observational Database and the IeDEA Southern Africa (International Epidemiologic Databases to Evaluate AIDS) regional cohorts.MethodsSurveys were conducted in April 2009. Analysis data from the Asia cohort were collected in March 2009 from 12 centres in Cambodia, India, Indonesia, Malaysia, and Thailand. Data from the IeDEA Southern Africa cohort were finalized in February 2008 from 10 centres in Malawi, Mozambique, South Africa and Zimbabwe.ResultsSurvey responses reflected inter-regional variations in drug access and national guidelines. A total of 1301 children in the TREAT Asia and 4561 children in the IeDEA Southern Africa cohorts met inclusion criteria for the cross-sectional analysis.Ten percent of Asian and 3.3% of African children were on second-line ART at the time of data transfer. Median age (interquartile range) in months at second-line initiation was 120 (78-145) months in the Asian cohort and 66 (29-112) months in the southern African cohort. Regimens varied, and the then current World Health Organization-recommended nucleoside reverse transcriptase combination of abacavir and didanosine was used in less than 5% of children in each region.ConclusionsIn order to provide life-long ART for children, better use of current first-line regimens and broader access to heat-stable, paediatric second-line and salvage formulations are needed. There will be limited benefit to earlier diagnosis of treatment failure unless providers and patients have access to appropriate drugs for children to switch to.
- ItemOpen AccessA case for integrating human rights in public health policy(2006) London, LeslieIn a global environment where human rights and well-being are coming under increasing threat, both from the spectre of terrorism and from the counter-reaction to it,1 and where international governance systems continue to pay lip service to poverty reduction while encouraging unbridled private accumulation of wealth resulting in huge inequalities between and within countries,2,3 the need to make human rights considerations an integral part of how public health policies are formulated cannot be overemphasised. Contestation over entitlements to socio-economic rights has troubled health care systems worldwide, from resource-poor settings in Africa, where questions have been raised as to whether human rights approaches are best suited to addressing the problem of AIDS in Africa,4,5 through to the over-consumptive USA where universal access to health care remains a policy objective doomed to unfulfilment under market-fixated economic systems.6,7
- ItemOpen AccessA Clinical audit of the transgender unit at Groote Schuur hospital(2021) Wilson, Allanah Joan; Torline, John; Marais, AdeleBackground The Transgender Clinic at Groote Schuur Hospital (GSH) – a large government funded academic hospital in Cape Town, South Africa - assists with the mental health assessment of transgender individuals and facilitates access to other gender affirming services, such as hormone therapy, plastic and reconstructive surgery, psychosocial, and legal services. Objectives This clinical audit aimed to gain a clearer understanding of the service and areas within the service which could be improved. To this end the general compliance of the clinical services of the multidisciplinary team (MDT) as recommended by the World Professional Association for Transgender Health 7th Version of Standards of Care for the Health of Transsexual, Transgender, and Gender Nonconforming People (WPATH SOC 7) was assessed. In addition, an analysis of the demographic and clinical characteristics of individuals attending the clinic and a review of waiting times and distance travelled to attend the clinic, was conducted. Methods The study was a clinical audit without a repeat data collection cycle. Participants included the MDT members working at GSH's Transgender Unit and individuals attending the Transgender Clinic from September 2018 to December 2019 (n = 50). All 11 MDT members were invited to participate in the study and were required to complete a data collection sheet related to their competency and experience. Data collection with respect to services provided, and waiting times for services, was captured from clinician administered standardized historytaking and assessment booklets and patient hospital folder reviews. Results All members of the MDT who participated met the WPATH SOC 7 competency requirements. The mean age of the individuals attending the GSH Transgender Clinic was 28 years. Forty-eight percent were employed, 36% unemployed and 16% full time scholars. The 7 mean waiting time for an initial appointment with mental health was 75 days, 73 days for endocrinology and 255 days for plastic surgery. Non- attendance at initial appointment was a factor across gender affirming services – 18% mental health service, 20.5% endocrinology and 27% plastic surgery. Forty-two percent of individuals screened positive for a co-occurring mental health condition with a third of these individuals having more than one mental health disorder. Mood and anxiety disorders co-occurred together most frequently. Seventy-five percent of individuals with an untreated or partially treated mental health concern were provided a therapeutic intervention at the time of initial assessment. The introduction of laboratory investigations being performed prior to the initial appointment with endocrinology resulted in a significant improvement in waiting time to the initiation of hormone therapy. Conclusion WPATH SOC 7 competency requirements were met by the GSH Transgender clinical team. Inconsistencies were found in the documentation of WPATH SOC 7 recommended clinician tasks within the mental health and endocrinology service. This is secondary to the layout of the standardized history taking and assessment booklet, and documentation of certain tasks being clinician dependent. Limited hospital resources and subsequent understaffing, long waiting times for appointments and gender-affirming surgery and lack of access to other services (e.g. fertility services) result in continued barriers to gender-affirming care.
- ItemOpen AccessA comparative analysis of pharmacists’ perspectives on codeine use and misuse – a three country survey(BioMed Central, 2018-03-27) Carney, Tara; Wells, John; Parry, Charles D H; McGuinness, Padraig; Harris, Richard; Van Hout, Marie CBackground The misuse of codeine is of increasing concern in a number of countries, particularly as this relates to over -the-counter pain and cough relief medication, and is also supplied as a prescription medicine. The study aimed to obtain and analyse the opinions and experience of pharmacy staff with regard to codeine misuse. Methods A cross-sectional web-based survey of pharmacy staff’s perspectives on this issue was administered through professional or regulatory bodies and completed by samples drawn in South Africa (n = 124), Ireland (n = 464) and the United Kingdom (n = 129). Results The majority of participants reported combination codeine-containing products as most popular, but significantly more pharmacy staff in South Africa reported codeine-containing cough syrups as most commonly popular (X2 = 122.7(2), p < 0.001). Codeine use was also seen significantly more of a public health problem in South Africa than in the other two countries (X2 = 7.6(2), p = 0.02). There was no difference across countries in the level of codeine misuse reported by pharmacy staff. Further findings indicate that professional training and education is desired, with unequivocal findings for the need for greater codeine control (X2 = 12.0(2), p = 0.002). Conclusion In conclusion, there were some inter-country differences, but overall the findings seem to suggest that pharmacists across all three countries view codeine misuse as a problem among their customers. Recommendations centre on risk management, surveillance and staff training.
- ItemOpen AccessA cross-sectional study of the association between cognitive impairment and haemoglobin levels in HIV-infected South Africans established on antiretroviral therapy(2019) Vermaak, John-Randel; Joska, John; Decloedt, EricBackground Sub-Saharan Africa, the epicenter of the global population of people living with HIV (PLHIV), is estimated to have more than 25 million PLHIV. In the era before the widespread availability of antiretroviral therapy (ART), anaemia (low serum haemoglobin) was a common clinical finding that was seen as a potential risk factor for HIV-associated neurocognitive impairment. The association between haemoglobin levels and neurocognitive function has not been assessed in a Sub-Saharan study population in the era of ART. Methods A cross-sectional secondary data analysis was performed to assess the association between serum haemoglobin level and neurocognitive function in 129 participants who had both neurocognitive test (global deficit score) and full blood count results performed as part of a randomised placebo controlled trial that evaluated the efficacy of lithium carbonate for the treatment of HIV associated neurocognitive disorders. Results The majority of our participants were female (87%) with a mean age of 37 ±7.78 years. Participants were all established on ART with a median CD4 count of 495 cells/µL (IQR=315- 629). The median haemoglobin level was 12.2 (IQR=11.6-13.00) and anaemia was present in 8.5%. Serum haemoglobin level was not associated with global deficit scores (GDS) and fewer years of education was the only independent risk association for GDS-defined neurocognitive impairment. Conclusion We found that in South Africans, who are established on ART, anaemia is less common than in the pre-ART era and importantly, that low-normal serum Hb levels do not present a risk for GDS-defined neurocognitive impairment. These findings are relevant as they show that aggressive management of low-normal Hb levels is not necessary provided individuals are otherwise clinically well and virally suppressed.
- ItemOpen AccessA descriptive study of a prosecuted group of child molesters(1990) Greenberg, David Mace
- ItemOpen AccessA descriptive study of the characteristics and discharge outcomes of acute psychiatric admissions at district and regional hospitals in the Cape Town Metropole region of South Africa(2019) Scheepers, Robin; Milligan, Peter; Lund, CrickBackground Mental disorders are the third most important contributor to the burden of disease in South Africa. In a resource-limited setting such as South Africa, rational mental health service planning requires assessment of the characteristics and outcomes of mental health services. Aim This study aimed to detail the characteristics and discharge outcomes of acute psychiatric admissions at district and regional hospitals in the Cape Town Metropolitan region of South Africa which serves an estimated population of 1.5 million people. Methods and Setting A retrospective descriptive cohort study was conducted, examining all acute psychiatric admissions from 1 April 2012 to 31 March 2013. Admission data were gathered from four hospitals in the catchment area of Valkenberg Hospital, a psychiatric hospital serving the Cape Town metro region. Results Psychotic and Mood disorders were the most common diagnostic categories. Male and older patients (>60 years), and those with substance-related disorders had significantly longer admissions. Transfer to psychiatric hospitals and internal transfers significantly increased the duration of admission. Admission to Groote Schuur Hospital was associated with a significantly longer length of stay. Patients were more likely to be readmitted within 30 days following discharge from district or regional hospitals than Valkenberg Hospital. Conclusion Several areas of focus to be addressed were identified, namely substance use interventions, access to specialized care at primary and secondary level and the need for additional specialist inpatient psychiatric resources. Further analysis of retention in care following discharge from district and regional hospitals is recommended to unpack factors that are associated with readmission.
- ItemOpen AccessA functional magnetic resonance imaging study of cognitive emotion regulation in relation to individual differences in self-esteem(2020) Swan, Freda Zoë; Groenewold, Nynke; Uhlmann, Anne; Stein, DanObjectives Self-esteem may affect the processing and regulation of emotion. However, it is unclear whether differences in self-esteem are associated with changes in initial emotional appraisal or engagement of emotion regulation. I investigated whether individual differences in self-esteem predicted brain responses to negative emotional stimuli: 1) when they were viewed without intentional regulation; and 2) during downregulation using cognitive reappraisal. Thirdly, I investigated whether self-esteem predicted reappraisal success. Method Twenty-nine healthy adults (age M=47, SD=15; 16 female) performed a cognitive reappraisal emotion regulation task during fMRI scanning. Participants viewed and subsequently reappraised or attended to negative and neutral images. Trait self-esteem (Rosenberg Self-Esteem Scale) was included as a predictor in a whole-brain multiple regression analysis. Analyses were thresholded at p<.005, k>p20, p<.05 family-wise error (FWE)-corrected at cluster-level. The anterior cingulate cortex (ACC; BA32) and the dorsal prefrontal cortex (PFC; BA6) were a priori regions of interest (ROI), since both have previously been reported in fMRI studies of self-esteem and cognitive reappraisal. A post-hoc ROI analysis tested the correspondence of self-esteem-related ACC activation with findings from a meta-analysis of emotion regulation. Ratings of negative emotional intensity following reappraisal trials were subtracted from ratings following attend-negative trials to index reappraisal success. Results Self-esteem was associated with potentiated ACC ROI activation during viewing of negative, compared to neutral, images (MNI x, y, z = -6, 17, 38, k=43, punc=.001 at peak, pFWE=.368 at cluster-level). For reappraisal compared to attended negative images, self-esteem was positively associated with activation in the left posterior insula (MNI x, y, z = -30, -10, 17, k=30, punc<.001 at peak, pFWE=.959 at cluster-level) and negatively associated with activation in the mid cingulate cortex (MNI x, y, z = 3, -34, 35, k=50, punc=.001 at peak, pFWE=.805 at clusterlevel). However, only the post-hoc ACC ROI analysis was significant after multiple comparison correction (MNI x, y, z = -6, 23, 38, k=22, punc=.001 at peak, pFWE=.021 at clusterlevel). For reappraisal, self-esteem was not related to activation in the ACC or dorsal PFC ROIs. Trait self-esteem did not correlate with reappraisal success, r =.16, p =.208. Conclusion Trait self-esteem may affect recruitment of the ACC during initial emotional appraisal. This may reflect successful automatic emotion regulation for high self-esteem, consistent with the demonstrated spatial overlap with a meta-analytic emotion regulation cluster. While selfesteem may affect brain responsivity during cognitive reappraisal, the observed trends must be interpreted carefully, since the findings do not survive correction for multiple comparisons, and emotional outcomes of applying reappraisal do not differ as a function of self-esteem. Taken together, these findings suggest that high trait self-esteem may be advantageous for rapid automatic emotion regulation, but not deliberate cognitive reappraisal.
- ItemOpen AccessA process evaluation exploring the lay counsellor experience of delivering a task shared psycho-social intervention for perinatal depression in Khayelitsha, South Africa(2017) Munodawafa, Memory; Lund, Crick; Schneider, MargueriteBACKGROUND: Task sharing of psycho-social interventions for perinatal depression has been shown to be feasible, acceptable and effective in low and middle-income countries. This study conducted a process evaluation exploring the perceptions of counsellors who delivered a task shared psycho-social counselling intervention for perinatal depression in Khayelitsha, Cape Town together with independent fidelity ratings. METHODS: Post intervention qualitative semi-structured interviews were conducted with six counsellors from the AFrica Focus on Intervention Research for Mental health (AFFIRM-SA) randomised controlled trial on their perceptions of delivering a task shared psycho-social intervention for perinatal depression. Themes were identified using the framework approach and were coded and analysed using Nvivo v11. These interviews were supplemented with fidelity ratings for each counsellor and supervision notes. RESULTS: Facilitating factors in the delivery of the intervention included intervention related factors such as: the content of the intervention, ongoing training and supervision, using a counselling manual, conducting counselling sessions in the local language (isiXhosa) and fidelity to the manual; counsellor factors included counsellors' confidence and motivation to conduct the sessions; participant factors included older age, commitment and a desire to be helped. Barriers included contextual factors such as poverty, crime and lack of space to conduct counselling sessions and participant factors such as the nature of the participant's problem, young age, and avoidance of contact with counsellors. Fidelity ratings and dropout rates varied substantially between counsellors. CONCLUSION: These findings show that a variety of intervention, counsellor, participant and contextual factors need to be considered in the delivery of task sharing counselling interventions. Careful attention needs to be paid to ongoing supervision and quality of care if lay counsellors are to deliver good quality task shared counselling interventions in under-resourced communities. TRIAL REGISTRATION: Clinical Trials: NCT01977326 , registered on 24/10/2013; Pan African Clinical Trials Registry: PACTR201403000676264 , registered on 11/10/2013.
- ItemOpen AccessA Retrospective Analysis of Referrals to Consultation-Liaison Psychiatry over a Five-Year Period in a Tertiary Hospital in South Africa(2022) Romburgh, Bailee Jean; Hoare, JacquelineObjective: The aim of this study was to review referrals to the consultation-liaison psychiatric service at Groote Schuur Hospital including the number of referrals, demographic details of referred patients, medical and psychiatric diagnoses, management and outcome over a five-year-period. It was anticipated that referrals had increased on an annual basis. Method: The study was observational and was conducted at Groote Schuur Hospital in Cape Town, South Africa. All inpatients referred to consultation-liaison psychiatry (CLP) during the study period were included. The study information was gathered via data capture sheets that are completed for patients referred to the division. Results: A total of 1978 patients were referred to CLP and analysed in the study. Most referrals occurred in 2018 (n=499; 25.2%). The majority of referrals came from the division of internal medicine (n=607; 30.7%), and the main reasons for referral were unspecified (n=402; 20.3%), suicide/risk assessment (n=333; 16.8%), and other symptoms of mental illness (n=264; 13.3%). The most frequent immediate management included medication initiation or adjustment (n=793; 40.1%), and supportive counselling/psychoeducation (n=511; 25.8%). Conclusion: Referral numbers to the division have increased during the study period as hypothesized. As expected, most referrals came from the internal medicine division. The results from this study highlight the importance of the consultation-liaison service at Groote Schuur Hospital.
- ItemOpen AccessA retrospective audit comparing state patients with schizophrenia and bipolar mood disorder who have committed violent crime admitted to the male forensic unit at Valkenberg Hospital(2018) Maharaj, Avani; Kaliski, SeanBackground There is a consensus that psychosis confers a modest risk toward violent offending. Most research to date has shown that a statistical relationship does exist between schizophrenia and bipolar disorder, and violence and aggressive behavior In forensic mental health, state patients are rehabilitated in a general program regardless of diagnosis. It is not known whether different rehabilitation management strategies should be implemented on those with bipolar disorder as compared to those with schizophrenia. This study is an attempt to ascertain if there are differences between those diagnosed with schizophrenia and bipolar disorders, and if so, whether these have implications for their rehabilitation programs. Objectives The study aims to compare the demographic profiles and comorbidities (in terms of substance use and personality disorders) of state patients with bipolar disorder and schizophrenia who have offended violently. Methods This was a quantitative, cross sectional study. State patients who were diagnosed with schizophrenia and bipolar disorder and committed a violent crime were included in the study from the 1st January 2000 to 31st December 2014. The study population comprised a total of 93 male state patients. Of these 46 patients had a diagnosis of bipolar disorder and 47 patients had a diagnosis of schizophrenia. Results The results show that in general the differences between the schizophrenia group and the bipolar disorder group are marginal. A higher percentage of patients with schizophrenia committed murder at 17.02% and attempted murder at 12.77%. The bipolar disorder group had a significantly higher number of patients diagnosed with co morbid personality disorder at 59.57% (p value of 0.01.) Substance abuse was common in both groups. The mean age at admission was 31,23 years in schizophrenia and 36,85 years in bipolar disorder. This demonstrates an earlier onset of criminality in the group with schizophrenia. Patients with bipolar disorder were more likely to be married (13.04%), divorced (10.8%) or separated (2.17%). Conclusion There were no major differences elicited between the 2 groups of patients. Certain aspects such as therapeutic programs for personality disordered patients and social interventions in patients with poor social support would contribute to improving the quality of the rehabilitation programs currently used. The commonalities found in the 2 groups suggest that a common approach to rehabilitation would be adequate in this setting.
- ItemOpen AccessA retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions(2018) Charles, Bhaskaran Nathamaniar; Horn, Neil; Williams-Ashman, PeterBackground: The impact on hospitalisations/ relapse rates of utilising long-acting antipsychotic injectable (LAIs) in a South African population suffering from chronic psychotic spectrum mental illness is poorly researched. Aim: To compare the duration and number of hospitalisation episodes 12 and 24 months before and after the initiation of a LAI. Setting: Valkenberg Hospital’s adult acute inpatient psychiatry services. Method: This was a retrospective naturalistic observational mirror-image study. Hospitalisation was utilised as a proxy for relapse. Results: Sixty-one patients were identified for the study. A comparison of the 12 months before LAI initiation to the 12 months following LAI initiation showed a reduction in the number of admissions of 44% (55 to 31), and a reduction in the number of inpatient days of 23% (1892 to 1464). There was a statistically significant reduction in the median number of hospital admissions (p = 0.005) and median inpatient days (p = 0.040). Comparing the 24 months before to the 24 months following LAI initiation, there was a reduction in the number of admissions of 30% (91 to 64) and inpatient days of 4% (3477 to 3355). There was a statistically significant reduction in the median number of hospital admissions (p = 0.014) and a non-statistically significant reduction in median days (p = 0.428). Conclusion: The prescription of a LAI reduced the duration and number of hospital admissions over a 12-month period. After 24 months, there were fewer admissions but no significant reduction in the number of inpatient days. This study supports findings of international mirror-image studies.
- ItemOpen AccessA retrospective study of outcomes after referral to the early intervention in psychosis programme at Valkenberg Psychiatric Hospital(2023) Setjie, Sewela; ; ; Horn, Neil; Rodwell CatherineBackground. Psychotic Disorders affect more than 1% of the South African adult population and have a chronic course that is associated with high rates of morbidity and mortality. The implementation of early intervention strategies may reduce the severity of these disorders. Little is known about the effectiveness of these interventions in South Africa and few longerterm studies have been undertaken internationally. Aim. This study aimed to measure the effectiveness of an Early Intervention and Support (EISH) service at reducing readmission to hospital in patients with psychotic disorders. Setting. Valkenberg Psychiatric Hospital, Cape Town. The EISH Team is an outpatient service consisting of psychiatrists, a psychologist, an occupational therapist, psychiatric nurses and social workers. Methods. Retrospective cohort study. Hospitalisation during the two years after discharge from the index admission was measured in 100 subjects who attended EISH and 100 who had treatment as usual (TAU). Readmission rate, average length of stay (ALOS), and time to readmission to District Hospitals (DH) and Tertiary Psychiatric Hospitals (TPH) were calculated. Results. Readmission Rates were three times higher in TAU compared to EISH patients for both types of Hospital. For TAU subjects compared to EISH subjects: ALOS was longer (59 vs 13 days), and days to readmission were fewer (187 vs 320 days). All differences were statistically significant (ps < .05). Conclusion. EISH intervention at Valkenberg Hospital was useful in reducing readmission rate, ALOS, and time to readmission in patients with Psychotic disorders. Prospective controlled trials are required to confirm the efficacy of this intervention.
- ItemOpen AccessA Review of Psychotropic drug prescription for patients with Intellectual disability at Alexandra Hospital (a specialist Intellectual Disability psychiatric hospital) outpatient clinic(2021) Akpabio, Idorenyin Ubon; Kleintjes, Sharon; Smith, PeterBackground: People with intellectual disability are more likely than the general population to be prescribed psychotropic agents. The most common indications include treatment of a psychiatric disorder and management of behaviours that challenge. Aim: The study aimed to assess the prescribing patterns of psychotropic medication to outpatients with intellectual disability at a psychiatric hospital. Setting: Alexandra hospital outpatient clinic, Cape Town. Methods: This was a retrospective folder and prescription chart review. Folders of all new patients (103) seen between January 2018 and August 2019 were examined at two points, the initial appointment and again at six months. The information was examined against the World Psychiatric Association (WPA) and the National Institute for Health and Care Excellence (NICE) guidelines for prescribing in people with intellectual disability. Results: psychotropic medication was prescribed to 88% of patients. Antipsychotics accounted for more than 56% of the medication prescribed and was used mainly to manage behaviours that challenge. Clinicians at Alexandra hospital followed prescribing guidelines to some extent; however, more still needs to be done to ensure best practice and care. Conclusion: This review revealed a few shortcomings in meeting prescribing guidelines by clinicians at Alexandra hospital. Measures to address these shortcomings could be the inclusion of medication review schedules and standardised forms for clerking and monitoring of side effects in patient files, the use of behavioural strategies as the primary management of behaviours that challenge, and the performance of regular clinical practice audits.
- ItemOpen AccessA situation analysis of mental health services and legislation in Ghana: challenges for transformation(2010) Ofori-Atta, A; Read, U M; Lund, Crick; Flisher, Alan; MHaPP Research Programme ConsortiumObjective: To conduct a situation analysis of the status of mental health care in Ghana and to propose options for scaling up the provision of mental health care. Method: A survey of the existing mental health system in Ghana was conducted using the WHO Assessment Instrument for Mental Health Systems. Documentary analysis was undertaken of mental health legislation, utilizing the WHO Legislation checklists. Semi-structured interviews and focus group discussions were conducted with a broad range of mental health stakeholders (n=122) at the national, regional and district levels. Results: There are shortfalls in the provision of mental health care including insufficient numbers of mental health professionals, aging infrastructure, widespread stigma, inadequate funding and an inequitable geographical distribution of services. Conclusion: Community-based services need to be delivered in the primary care setting to provide accessible and humane mental health care. There is an urgent need for legislation reform, to improve mental health care delivery and protect human rights.
- ItemOpen AccessA situational analysis of child and adolescent mental health services in Ghana Uganda South Africa and Zambia(2010) Kleintjies, Sharon Rose; Lund, Christopher; Flisher, A J; MHaPP Research Programme ConsortiumObjective: Approximately one in five children and adolescents (CA) suffer from mental disorders. This paper reports on the findings of a situational analysis of CA mental health policy and services in Ghana, Uganda, South Africa and Zambia. The findings are part of a 5 year study, the Mental Health and Poverty Project, which aims to provide new knowledge regarding multi-sectoral approaches to breaking the cycle of poverty and mental ill-health in Africa. Method: The World Health Organization’s Assessment Instrument for Mental Health Systems (WHO-AIMS) Version 2.2 was used to collect quantitative information on mental health resources. Mental health policies and legislation were analysed using the WHO Policy and Plan, and Legislation Checklists. Qualitative data were collected through focus groups and interviews. Results: Child and adolescent mental health (CAMH) - related legislation, policies, services, programmes and human resources are scarce. Stigma and low priority given to mental health contribute to low investment in CAMH. Lack of attention to the impoverishing impact of mental disorders on CA and their families contribute to the burden. Conclusion: Scaling up child and adolescent mental health services (CAMHS) needs to include anti-stigma initiatives, and a greater investment in CAMH. Clear policy directions, priorities and targets should be set in country-level CAMH policies and plans. CAMHS should be intersectoral and include consideration of the poverty- mental health link. The roles of available mental health specialists should be expanded to include training and support of practitioners in all sectors. Interventions at community level are needed to engage youth, parents and local organizations to promote CAMH.
- ItemRestrictedA Straight Left Heart Border: A New Radiological Sign of a Hemopericardium(2014) Nicol, Andrew John; Navsaria, Pradeep Harkison; Beningfield, Steve; Kahn, DelawirBackground: Detection of a cardiac injury in a stable patient after a penetrating chest injury can be difficult. Ultrasound of the pericardial sac may be associated with a false negative result in the presence of a hemothorax. A filling in of the left heart border inferior to the pulmonary artery, called the straight left heart border (SLHB), is a radiological sign on chest X-ray that we have found to be associated with the finding of a hemopericardium at surgery. The aim of the present study was to determine if this was a reliable and reproducible sign. Methods: This was a prospective study of patients with a penetrating chest injury admitted between 1 October 2001 and 28 February 2009, who had no indication for immediate surgery, and were taken to the operating room for creation of a subxiphoid pericardial window (SPW). The chest X-ray was reviewed by a single trauma surgeon prior to surgery. Results: A total of 162 patients with a possible occult cardiac injury underwent creation of a SPW. Fifty-five of the 162 patients (34 %) were noted to have a SLHB on chest X-ray and a hemopericardium confirmed at SPW. The sensitivity of the SLHB sign was 40 %; specificity, 84 %; and positive predictive value, 89 %. (p = 0.005, Odds ratio 3.48, lower 1.41, upper 8.62). Conclusions: The straight left heart border is a newly described radiological sign that was highly significant in predicting the presence of a hemopericardium and should alert the clinician to a possible occult cardiac injury.
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- ItemOpen AccessAccelerating Sustainable Development Goals for South African adolescents from high HIV prevalence areas: a longitudinal path analysis(2021-11-11) Meinck, Franziska; Orkin, Mark; Cluver, LucieBackground Adolescents experience a multitude of vulnerabilities which need to be addressed in order to achieve the Sustainable Development Goals (SDGs). In sub-Saharan Africa, adolescents experience high burden of HIV, violence exposure, poverty, and poor mental and physical health. This study aimed to identify interventions and circumstances associated with three or more targets (“accelerators”) within multiple SDGs relating to HIV-affected adolescents and examine cumulative effects on outcomes. Methods Prospective longitudinal data from 3401 adolescents from randomly selected census enumeration areas in two provinces with > 30% HIV prevalence carried out in 2010/11 and 2011/12 were used to examine six hypothesized accelerators (positive parenting, parental monitoring, free schooling, teacher support, food sufficiency and HIV-negative/asymptomatic caregiver) targeting twelve outcomes across four SDGs, using a multivariate (multiple outcome) path model with correlated outcomes controlling for outcome at baseline and socio-demographics. The study corrected for multiple-hypothesis testing and tested measurement invariance across sex. Percentage predicted probabilities of occurrence of the outcome in the presence of the significant accelerators were also calculated. Results Sample mean age was 13.7 years at baseline, 56.6% were female. Positive parenting, parental monitoring, food sufficiency and AIDS-free caregiver were variously associated with reductions on ten outcomes. The model was gender invariant. AIDS-free caregiver was associated with the largest reductions. Combinations of accelerators resulted in a percentage reduction of risk of up to 40%. Conclusion Positive parenting, parental monitoring, food sufficiency and AIDS-free caregivers by themselves and in combination improve adolescent outcomes across ten SDG targets. These could translate to the corresponding real-world interventions parenting programmes, cash transfers and universal access to antiretroviral treatment, which when provided together, may help governments in sub-Saharan Africa more economically to reach their SDG targets.
- ItemOpen AccessAcceptability and feasibility of peer-administered group interpersonal therapy for depression for people living with HIV/AIDS—a pilot study in Northwest Ethiopia(2021-07-28) Asrat, Biksegn; Lund, Crick; Ambaw, Fentie; Schneider, MargueriteBackground Psychological treatments are widely tested and have been effective in treating depressive symptoms. However, implementation of psychological treatments in the real world and in diverse populations remains difficult due to several interacting barriers. In this study, we assessed the acceptability and feasibility of peer-administered group interpersonal therapy for depressive symptoms among people living with HIV/AIDS in Northwest Ethiopia. Method We conducted a single-arm, peer-administered, group interpersonal therapy intervention with eight weekly sessions from 15 August to 15 December 2019 among people living with HIV/AIDS in Northwest Ethiopia. Four interpersonal therapy groups were formed for the intervention with a total of 31 participants. Results Of the 31 recruited participants, 29 completed the intervention providing a retention rate of 93.5%. The process of the intervention and its outcomes were highly acceptable as most participants expressed success in resolving their psychosocial problems, adjusting to life changes and coping with stigma. The intervention was also reported to be feasible despite anticipated barriers such as access to transportation, perceived stigma and confidentiality concerns. The post-intervention assessment revealed significant reduction in depressive symptoms (mean difference (MD) = 9.92; t = − 7.82; 95% CI, − 12.54, − 7.31; p < 0.001), improvement in perceived social support (MD = 0.79; t = 2.84; 95% CI, 0.22, 1.37; p = 0.009) and quality of life (MD = 0.39; t = 4.58; 95% CI, 0.21, 0.56; p < 0.001). Conclusion Group interpersonal therapy is feasible and acceptable, and people living with HIV/AIDS can benefit from group interpersonal therapy in managing depressive symptoms and in improving perceived social support and quality of life. Future studies should examine the effectiveness of group interpersonal therapy in this setting.